THE EFFECT OF ADRENALIN ON THE BLOOD PRESSURE OF THE ELASMOBRANCH, SQUALUS ACANTHIAS

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Abstract
1. Intravenous injection of adrenalin, in doses as low as 2 cc. of 1 : 500,000, produced long-sustained pressor effects in Squalus acanthias, together with marked increase of pulse pressure and a tendency toward decrease of heart rate. 2. Subsequent doses of adrenalin following doses stronger than 1: 500,000 were ineffective. This is interpreted as being due to already existing maximum pressor action. Doses subsequent to a dose of 2 cc. of 1: 500,000 were effective. 3. The pressor effect is interpreted as being due to extra-cardiac factors, peripheral to the gill capillaries, but the region of action of the adrenalin was not located.

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