Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc
- 1 September 2006
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (17) , 4633-4637
- https://doi.org/10.1016/j.bmcl.2006.06.012
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Initial synthesis of UK-427,857 (Maraviroc)Tetrahedron Letters, 2005
- A Practical Synthesis of Piperidine-/Tropane-Substituted 1,2,4-TriazolesSynlett, 2005
- Structural Determinants of HERG Channel Block by Clofilium and IbutilideMolecular Pharmacology, 2004
- Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segmentBioorganic & Medicinal Chemistry Letters, 2004
- The impact of drug-induced QT interval prolongation on drug discovery and developmentNature Reviews Drug Discovery, 2003
- Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome: Insights from a CoMFA Study of HERG K+ Channel BlockersJournal of Medicinal Chemistry, 2002
- New p-Methylsulfonamido Phenylethylamine Analogues as Class III Antiarrhythmic Agents: Design, Synthesis, Biological Assay, and 3D-QSAR AnalysisJournal of Medicinal Chemistry, 2002
- Molecular and Cellular Mechanisms of Cardiac ArrhythmiasCell, 2001
- A structural basis for drug-induced long QT syndromeProceedings of the National Academy of Sciences, 2000