A model for the binding of lac repressor to the lac operator
- 1 April 1976
- journal article
- research article
- Published by Springer Nature in Molecular Biology Reports
- Vol. 2 (5) , 427-434
- https://doi.org/10.1007/bf00366265
Abstract
A model is suggested for the lac repressor binding to the lac operator in which the repressor polypeptide chain sequences from Gly 14 to Ala 32 and from Ala 53 to Leu 71 are involved in specific interaction with operator DNA. A correspondence between the protein and DNA sequences is found which explains specificity of the repressor binding to the lac operator. The model can be extended to describe specific binding of other regulatory proteins to DNA.Keywords
This publication has 18 references indexed in Scilit:
- Predicted secondary structure of the N-terminal sequence of the lac repressor and proposed models for its complexation to the lac operatorBiochemistry, 1975
- Genetic Regulation: The Lac Control RegionScience, 1975
- lac Repressor-operator interaction: IX. The binding of lac repressor to operators containing Oc mutationsJournal of Molecular Biology, 1974
- Sequences of Controlling Regions of the Lactose OperonPublished by Cold Spring Harbor Laboratory ,1974
- The Nucleotide Sequence of the lac OperatorProceedings of the National Academy of Sciences, 1973
- The Amino-Acid Sequence of lac RepressorProceedings of the National Academy of Sciences, 1973
- Altered Sequences Changing the Operator-Binding Properties of the Lac Repressor: Colinearity of the Repressor Protein with the i -Gene MapProceedings of the National Academy of Sciences, 1972
- How lac Repressor Binds to DNANature, 1972
- lac repressor—Operator interaction: II. Effect of galactosides and other ligandsJournal of Molecular Biology, 1970
- Mutants that make more lac repressor.Proceedings of the National Academy of Sciences, 1968