Dysmyelination in “Jimpy” Mouse

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Abstract
Abnormalities in oligodendroglial cells and nodal regions of the myelinated fibers in spinal cord and optic nerve of the mutant mouse Jimpy are described. Membranous tubes were found in the oligodendroglial cells which may have derived from abnormal membrane formation in these cells, thus representing dystopic myelin membrane formation. The rare myelin sheaths present in the Jimpy spinal cord were never found to extend over a distance greater than one internode. They terminated in halfnode structures which often showed abnormalities in the relation between axon and myelin sheath. These observations are interpreted to be further indications that the Jimpy defect consists of a dysmyelination due to oligodendroglial insufficiency.

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