Renal Reabsorption of Phosphate in Normal Human Subjects and in Patients with Parathyroid Disease

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Abstract
Renal tubular reabsorption of phosphate was measured in normal and hypoparathyroid subjects at normal and elevated plasma phosphate levels. A maximal rate of phosphate reabsorption was found in all subjects. Considerable variability in the rate of maximal tubular reabsorption of phosphate occurs within a given experiment and also between experiments. This variability remains unexplained. Dietary variations in Ca and P produced no consistent changes in phosphate reabsorption. Comparison of the maximal rates of phosphate reabsorption between normal individuals indicated a wide range of values. Values in hypoparathyroid subjects fell within the broad range of normal. The variability of the maximal rate of phosphate reabsorption in a given individual and between individuals makes it necessary for each subject to serve as his own control in any study designed to determine the influence of an experimental regimen on phosphate reabsorption.