Hormone-Dependent Differentiation of Mammary Gland: Sequence of Action of Hormones in Relation to Cell Cycle
- 19 May 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3777) , 945-946
- https://doi.org/10.1126/science.156.3777.945
Abstract
Differentiation of mouse mammary gland in vitro requires insulin, hydrocortisone, and prolactin. The epithelial cells must first divide in order to synthesize casein in response to these hormones. Insulin is required for the initiation of DNA synthesis and is also necessary during G1 phase (after mitosis). Prolactin can elicit the overt differentiative responses after mitosis. Activity of hydrocortisone precedes that of prolactin, that is, after mitosis it is not capable of eliciting the differentiative response.This publication has 7 references indexed in Scilit:
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