Effect of Hypophysectomy on Feed Intake in Rats.

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Abstract
Summary The effect of hypophysectomy on feed consumption in the rat was determined by two methods. A reduction was observed when operated rats were compared with sham-operated controls, and the feed consumption of the same rats before and after the operation was compared. The two methods indicated that hypophysectomy reduced the mean daily feed intake about 30%: These results are quite similar to the observation that the combined operations of thyroidectomy and adrenalectomy reduced feed intake about 30%, indicating that the lack of thyroxine and corticosterone may be the major hormones concerned in feed intake of those secreted by the pituitary and its target glands.

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