The Waning Effect of Postmenopausal Estrogen Therapy on Osteoporosis

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Abstract
Almost all physicians and their patients believe that estrogen treatment can prevent osteoporosis. Evidence from the Framingham Study reported in this issue of the Journal supports this hypothesis1. In women less than 75 years old who had received long-term estrogen therapy, bone mineral density was higher than in women who had never taken estrogen. In women more than 75 years old, however, there was little difference in bone density between women who had taken estrogen and those who had not. How can we reconcile these results with what is known about the effect of estrogen on the risk of . . .