Recurrent inhibition and afterhyperpolarization following motoneuronal discharge in the cat.

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Abstract
The relation between the size of a monosynaptic reflex (varying from the smallest values to the maximal motor response) and the output from Renshaw cells was investigated. This relation was extremely variable from 1 Renshaw cell to another. A linear relation between the reflex size and the early discharge emerged when the responses of all the Renshaw cells were averaged or when the summed activity of a pool of Renshaw cells was estimated by recording the recurrent inhibition in their target motoneurons. The lowest threshold motoneurons were efficient in producing recurrent inhibition. In motoneurons, recorded intracellularly, the size of the depression caused by the afterhyperpolarization was compared to the maximum autogenetic recurrent inhibition. Under the particular experimental conditions used to mimic human experiments (Hultborn and Pierrot-Deseilligny, 1979), recurrent inhibition had the same order of magnitude as the depression caused by afterhyperpolarization. The additional depression caused by the summation of afterhyperpolarizations of 2 consecutive spikes was measured. A summation of importance equal to the maximum autogenic recurrent inhibition required a mean interspike interval of 25 ms.

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