Radionuclide Diagnosis of Splenic Rupture in Infectious Mononucleosis

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Abstract
Spontaneous splenic rupture [in humans] is a rare but serious complication of infectious mononucleosis. Although radionuclide spleen imaging is a well accepted method for diagnosis of traumatic rupture, interpretation can be difficult in the setting of mononucleosis, as tears may be ill-defined and diagnosis hampered by inhomogeneous splenic uptake. Four proven cases of spontaneous rupture are presented, 3 of which illustrate these diagnostic problems.