Sphingosine-1-Phosphate as an Intercellular Signaling Moleculea
- 1 June 1998
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 845 (1 SPHINGOL) , 19-31
- https://doi.org/10.1111/j.1749-6632.1998.tb09659.x
Abstract
Sphingosine-1-phosphate (Sph-1-P) has been implicated as an intracellular second messenger in many studies. Previously, we found the roles of Sph-1-P as a platelet activating lipid released from stimulated platelets and as a lipid regulator of cell motility. We first investigated the mechanism by which Sph-1-P induces activation in platelets. Although exogenous Sph-1-P activated platelets, intracellular Sph-1-P formed from exogenously added Sph failed to do so. Supporting the notion that exogenous Sph-1-P stimulates platelets from outside, we found that contact of platelet surfaces with Sph-1-P-immobilized glass beads resulted in platelet activation. Using these glass beads, we next found that exogenously added Sph-1-P inhibits F10 cell motility from outside through its specific binding site(s) on the cell. We finally identified putative receptor protein(s) for Sph-1-P on the surface of F10 cells.Keywords
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