Anti‐annexin V antibody in systemic lupus erythematosus patients with lupus anticoagulant and/or anticardiolipin antibody
- 1 September 1994
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 47 (1) , 56-58
- https://doi.org/10.1002/ajh.2830470112
Abstract
We investigated anti-annexin V antibody (aANX) in patients with systemic lupus erythe-matosus (SLE), and correlated to positivity with lupus anticoagulant (LA)/anticardiolipin antibody (aCL). aANX was positive in 12/47 SLE patients (26%), including 7 with β2-glycoprotein 1 (GPl)-dependent aANX. The positivity of aANX was higher in patients with aCL (19%) and LA/aCL (50%) than in those without LA/aCL (10%). From these results, it is concluded that aANX is an autoantibody closely related to LA/aCL, and can be a possible new risk marker for thrombosis.Keywords
This publication has 8 references indexed in Scilit:
- Detection of Beta-2-Glycoprotein-l-Dependent Antiphospholipid Antibodies and Anti-Beta-2-Glyco-protein-l Antibody in Patients with Systemic Lupus Erythematosus and in Patients with SyphilisInternational Archives of Allergy and Immunology, 1994
- Distinguishing β2‐glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20British Journal of Haematology, 1993
- Effects of annexin V on the activity of the anticoagulant proteins C and SThrombosis Research, 1993
- Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor.The Journal of Immunology, 1992
- Guidelines for Testing and Revised Criteria for Lupus AnticoagulantsThrombosis and Haemostasis, 1991
- Phospholipid binding properties of human placental anticoagulant protein-I, a member of the lipocortin familyJournal of Biological Chemistry, 1989
- Structure and Expression of cDNA for an Inhibitor of Blood Coagulation Isolated from Human Placenta: A New Lipocortin-Like ProteinThe Journal of Biochemistry, 1987