Phenytoin and Carbamazepine in Production of Cleft Palates in Mice
- 1 December 1979
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 36 (13) , 832-836
- https://doi.org/10.1001/archneur.1979.00500490046007
Abstract
• The teratogenic activity of two anticonvulsant drugs, phenytoin sodium and carbamazepine, was studied in pregnant mice fed phenytoin and carbamazepine during days 8 to 13. Incidence of palatal defects and other abnormalities correlated with increasing dosages and blood levels of the drugs. Phenytoin produced a much higher incidence of teratogenic effects than carbamazepine.This publication has 9 references indexed in Scilit:
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