Metabolism and elimination of quinine in healthy volunteers

Abstract
The aims were to investigate: (1) The renal elimination of quinine and its metabolites 3-hydoxyquinine, 2′-quininone, (10R) and (10S)-11-dihydroxydihydroquinine and (2) the relative importance of CYP3A4, CYP1A2 and CYP2C19 for the formation of 2′-quininone, (10R) and (10S)-11-dihydroxydihydroquinine in vivo.