Circulating Interferon-like Viral Inhibitor in Patients with Meningitis Due toHaemophilus influenzae

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Abstract
IT has been reported that other materials than viruses may induce the formation of interferon.1 , 2 In particular, interferon-like viral inhibitors have been produced by gram-negative bacteria in chickens1 and mice3 and by bacterial endotoxins in mice3 and in rabbits.4 These results in animals suggested to us the possibility that an interferon-like viral inhibitor would also develop in human patients with gram-negative bacteremia or with endotoxemia. The present report describes the demonstration of such an inhibitor in 2 patients with meningitis and bacteremia caused by Haemophilus influenzae. Materials and MethodsGeneralSerial blood samples were obtained by venipuncture, and serums were . . .