Effect of acetazolamide on dog parotid saliva

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Abstract
Canine parotid saliva was obtained at varying secretory rates by the stimulation of the postganglionic parasympathetic nerve. Analysis revealed this secretion to have a CO2 content of about 20–30 mEq/liter at low rates of salivary flow to 50– 60 mEq/liter at high flow rates. After the intravenous administration of acetazolamide, the CO2 content at high flow did not rise much above those levels attained at low secretory rates. Acetazolamide also caused decrease of sodium concentration and an increase in chloride concentration at high rates of secretion.