A Clinical Trial of Amitriptyline in Depressive Patients

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Abstract
Amitriptyline (Tryptizol) is an antidepressant drug which is related structurally to imipramine (Fig. 1). Its full name chemically is 5-(d-dimethylaminopropylidene)-dibenzo (a,d) (1,4) cycloheptadiene hydrochloride. Numerous uncontrolled trials to date (Ayd, Bennett) have reported success with this drug in the treatment of both endogenous and reactive depressions. Several reports (Ayd, Dorfman, Dunlop) have stressed the fact that agitation as a manifestation of depressive illness is frequently relieved. The purpose of this study was to assess the effect of the drug on depression in a controlled trial.

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