Treatment of Hypercalciuria

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Abstract
Half of the men and 75 per cent of the women in whom calcium oxalate renal stones form excrete more than 4 mg of urinary calcium per kilogram of body weight daily1 because they have a familial2 normocalcemic form of hypercalciuria. Of the remainder, many others have less severe hypercalciuria that raises their risk of stones.3 High urinary excretion of calcium promotes the formation of calcium oxalate crystals by increasing urine supersaturation,4 and measures that reduce calcium excretion reduce rates of stone formation. For example, thiazide diuretic agents lower urinary calcium excretion by 50 per cent, and the rate of . . .