Inhibitors of Repair of Potentially Lethal Damage and DNA Polymerases Also Influence the Recovery of Potentially Neoplastic Transforming Damage in C3H10T-1/2 Cells
- 1 July 1990
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 123 (1) , 49-54
- https://doi.org/10.2307/3577656
Abstract
The effects of aphidicolin and .beta. Ara A on radiation sensitivity were evaluated in terms of cell killing, recovery, and neoplastic transformation in the C3H10T-1/2 cell system. When cells were held in plateau phase, recovery of potentially lethal damage (PLD) and potentially transforming damage (PTD) occurred. The addition of .beta. Ara A resulted in reduced PLD recovery for both the survival and neoplastic transformation end points. The addition of aphidicolin did not affect recovery of PLD or PTD. These data show that the inhibition of polymerase .alpha. by aphidicolin does not affect recovery of damage leading to cell death or neoplastic transformation. However, the inhibition of both polymerase .alpha. and .beta. by .beta. Ara A resulted in inhibition of recovery of damage leading to both cell death and neopalstic transformation. These data indicated that polymerase .beta. may be involved in both PLD and PTD recovery.This publication has 5 references indexed in Scilit:
- Reduced pH Increases Recovery from Radiation Damage Potentially Leading to Cell Death and toin VitroTransformationInternational Journal of Radiation Biology, 1988
- ONCOGENIC TRANSFORMATION OF C3H10T1/2 MOUSE EMBRYO CELLS BY X-RAYS, HYPERTHERMIA, AND COMBINED TREATMENTS1986
- Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis.Proceedings of the National Academy of Sciences, 1984
- EFFECTS OF THE NUCLEOSIDE ANALOGS ALPHA-ARA-A, BETA-ARA-A AND BETA-ARA-C ON CELL-GROWTH AND REPAIR OF BOTH POTENTIALLY LETHAL DAMAGE AND DNA DOUBLE STRAND BREAKS IN MAMMALIAN-CELLS IN CULTURE1983
- Effect of Hyperthermia on CHO DNA Polymerases α and βRadiation Research, 1982