The Flow Field along the Entire Length of Mouse Aorta and Primary Branches
- 26 February 2008
- journal article
- Published by Springer Nature in Annals of Biomedical Engineering
- Vol. 36 (5) , 685-699
- https://doi.org/10.1007/s10439-008-9473-4
Abstract
There is a spatial disposition to atherosclerosis along the aorta corresponding to regions of flow disturbances. The objective of the present study is to investigate the detailed distribution of hemodynamic parameters (wall shear stress (WSS), spatial gradient of wall shear stress (WSSG), and oscillatory shear index (OSI)) in the entire length of C57BL/6 mouse aorta with all primary branches (from ascending aorta to common iliac bifurcation). The detailed geometrical parameters (e.g., diameter and length of the vessels) were obtained from casts of entire aorta and primary branches of mice. The flow velocity was measured at the inlet of ascending aorta using Doppler flowprobe in mice. The outlet pressure boundary condition was estimated based on scaling law. The continuity and Navier–Stokes equations were solved using three-dimensional finite element method (FEM). The model prediction was tested by comparing the computed flow rate with the flow rate measured just before the common iliac bifurcation, and good agreement was found. It was also found that complex flow patterns occur at bifurcations between main trunk and branches. The major branches of terminal aorta, with the highest proportion of atherosclerosis, have the lowest WSS, and the relatively atherosclerotic-prone aortic arch has much more complex WSS distribution and higher OSI value than other sites. The low WSS coincides with the high OSI, which approximately obeys a power law relationship. Furthermore, the scaling law between flow and diameter holds in the entire aorta and primary branches of mice under pulsatile blood flow conditions. This model will eventually serve to elucidate the causal relation between hemodynamic patterns and atherogenesis in KO mice.Keywords
This publication has 41 references indexed in Scilit:
- Allometric scaling of wall shear stress from mice to humans: quantification using cine phase-contrast MRI and computational fluid dynamicsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2006
- Surface Deformation and Convection in Electrostatically-Positioned Droplets of Immiscible Liquids Under MicrogravityJournal of Heat Transfer, 2005
- Three-dimensional Marangoni convection in electrostatically positioned droplets under microgravityInternational Journal of Heat and Mass Transfer, 2004
- Distribution of stress and strain along the porcine aorta and coronary arterial treeAmerican Journal of Physiology-Heart and Circulatory Physiology, 2004
- Models of Experimental Hypertension in MiceHypertension, 1996
- Characterization of sites with elevated LDL permeability at intercostal, celiac, and iliac branches of the normal rabbit aorta.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1994
- Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein EScience, 1992
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsPublished by Elsevier ,1992
- Quantitative measurements of early atherosclerotic lesions on rabbit aortae from vascular castsAtherosclerosis, 1989
- THE PHYSIOLOGICAL PRINCIPLE OF MINIMUM WORK APPLIED TO THE ANGLE OF BRANCHING OF ARTERIESThe Journal of general physiology, 1926