Human renin in transgenic mouse kidney is localized to juxtaglomerular cells
- 1 September 1991
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 278 (2) , 601-603
- https://doi.org/10.1042/bj2780601
Abstract
To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the renin-production site by immunohistochemistry. By using a monoclonal antibody specific for human renin, A6-11-6, we demonstrated that human renin in the transgenic mouse kidney is localized to the juxtaglomerular cells of afferent arterioles.Keywords
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