Influence of Low Dose of 2-Acetylaminofluorene on Liver Tumorigenesis in Mice.

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Abstract
Summary Administration by stomach tube of a suspension containing 2-acetylaminofluorene to suckling albino mice was followed by development of high incidence of hepatomas in males (60%) but not in females (1%). A similarly low incidence of hepatomas (0%-4%) was observed in untreated mice from same strain or mice treated with suspension alone. The low dose of 2-acetylaminofluorene represents smallest quantity of this compound effective to date in liver tumorigenesis. Also, results indicate that suckling male mouse is especially susceptible to hepatoma induction with 2-acetylaminofluorene.

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