Structural analysis and comparison of the C‐terminal transport signal domains of hemolysin A and leukotoxin A

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Abstract
NMR spectroscopy was used to study the structure of the C‐terminal signal sequences of the bacterial toxins, hemolysin A(HlyA) and leukotoxin A (LktA). The two signals share little sequence homology; however, both can direct toxin transport with equal efficiency. We report here that in a membrane mimetic environment both peptides form two short non‐interacting α‐helices separated by a short loop. This higher order structure may be a common feature of C‐terminal signals and may be required for interaction with the membrane associated transporter complex.