Molecular Cloning and Sequencing of the F and 22K Membrane Protein Genes of the RSS-2 Strain of Respiratory Syncytial Virus
- 1 November 1987
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 68 (11) , 2789-2796
- https://doi.org/10.1099/0022-1317-68-11-2789
Abstract
The nucleotide sequences of the adjacent genes coding for the F protein and 22K protein of the RSS-2 strain of human respiratory syncytial (RS) virus were determined from cDNA clones of genomic RNA. Comparison of these sequences and the inferred amino acid sequences of the F and 22K proteins with the corresponding published sequences of another subgroup A virus, the A2 strain of RS virus, reveals extensive overall homology (> 95%) at both the nucleotide and amino acid levels, even though these two viruses were isolated 15 years apart in different continents. The intergenic region and the hydrophobic amino-terminal signal sequence of the F proteins of the two viruses, however, are much less conserved.This publication has 1 reference indexed in Scilit:
- Nucleotide sequence of the gene encoding respiratory syncytial virus matrix proteinJournal of Virology, 1984