An Enzymatic Mechanism for Linking Amino Acids to RNA
Open Access
- 1 February 1958
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 44 (2) , 78-86
- https://doi.org/10.1073/pnas.44.2.78
Abstract
An enzymatic system for linking amino acids to RNA is described. The incorporation of a single amino acid requires the corresponding amino acid-activating enzyme, a specific RNA fraction, ATP and Mg++. The amino acid-activating enzyme appears to catalyze both the formation of the adenyl amino acid and the transfer of the amino acid moiety to RNA. Experiments with several amino acids indicate that there are specific binding sites for these amino acids associated with the RNA.Keywords
This publication has 18 references indexed in Scilit:
- ENZYMATIC CARBOXYL ACTIVATION OF AMINO ACIDSPublished by Elsevier ,2021
- STUDIES ON THE INITIAL STEP OF FATTY ACID ACTIVATIONJournal of Biological Chemistry, 1957
- The isolation of a tryptophan-activating enzyme from pancreasArchives of Biochemistry and Biophysics, 1956
- ACYL ADENYLATES: THE INTERACTION OF ADENOSINE TRIPHOSPHATE AND l-METHIONINEJournal of Biological Chemistry, 1956
- An amino acid dependent exchange between 32P labeled inorganic pyrophosphate and ATP in microbial extractsBiochimica et Biophysica Acta, 1956
- ACYL ADENYLATES: AN ENZYMATIC MECHANISM OF ACETATE ACTIVATIONPublished by Elsevier ,1956
- The Problem of Information Transfer from the Nucleic Acids to ProteinsPublished by Elsevier ,1956
- THE PREPARATION AND CHARACTERIZATION OF RIBONUCLEIC ACIDS FROM YEASTJournal of Biological Chemistry, 1955
- [Duplicating mechanism for peptide chain and nucleic acid synthesis].1952
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951