In vivo Evidence that Ethosuximide Is a Substrate for Cytochrome P450IIIA
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 45 (3) , 121-128
- https://doi.org/10.1159/000138990
Abstract
The role of various subfamilies of rat hepatic cytochrome P450 in the oxidation of ethosuximide was evaluated by comparing ethosuximide clearance in control rats and those pretreated with relatively selective P450 inducers and/or inhibitors. Clotrimazole pretreatment increased ethosuximide clearance threefold (pKeywords
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