THE RELATIONSHIP OF TEMPERATURE AND INSULIN DOSAGE TO THE RISE IN PLASMA AMINO NITROGEN IN THE EVISCERATED RAT1

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Abstract
The rate of increase of the plasma amino N of rats after evisceration was shown to be a function of body temp., the increase in rate being approx. 9% per degree C increase in temp. This observation reconciles differences in rates reported by previous authors (Frame and Russell, Ingle, Prestrud, and Nezamis). The effects of insulin on the increase in plasma amino N were compared at 29[degree] and at 38[degree]C. While complete suppression of the usual increase in plasma amino N was obtained with 1 unit of insulin per kg. per hr. at 29[degree], only partial suppression was obtained with this dose at 38[degree]; and it appeared that from 10 to 50 times as much insulin would be required to produce the same relative degree of suppression at the higher temp. as at the lower. A sample of insulin freed of the glycogenolytic factor was found to be as effective as ordinary insulin in suppressing the increase in plasma amino N in the eviscerated rat.