Aspirin and Gastrointestinal Bleeding

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Abstract
From history-taking and from analysis of patient plasma salicylate levels a link exists between aspirin and gastrointestinal bleeding in 68% of the cases. Salicylate levels alone indicate that aspirin is taken in 22% of the cases. Plasma salicylate measurement and endoscopy allow a better understanding of hemorrhagic lesions due to aspirin. Aspirin is responsible especially for hemorrhage from ulcers and acute gastritis or duodenitis. Aspirin is dangerous in a moderate number of susceptible individuals, such as those with peptic ulcer constitution or cirrhosis.

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