Changes of the Ta Wave in Standard Leads Following Stimulation of the Vagus Nerves.

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Abstract
In dogs, anesthetized with nembutal, the heart was exposed and the vagus nerves were severed in the neck. In all of 17 expts. faradic stimulation of the peripheral end of the right or left vagus nerve in the neck caused a depression of the P-R interval lasting for about 7-12 beats. The changes were found in all leads but were most pronounced in lead 2. No evidence of fatigue was observed. Right and left vagus were equally effective. Increased duration of the vagal stimulation did not lead to longer lasting changes of the Ta wave. Intraven. injn. of 0.005 g. of acetylcholine caused the same changes. Carotid pressure in man was also followed for a few beats by a depressed P-R interval. These changes are explained by a shortened re-polarization process of the auricular muscle during and shortly after stimulation.

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