A Study of the Effects of the Anti-Rheumatic Drug Ibuprofen (Brufen®) on Patients Being Treated with the Oral Anti-Coagulant Phenprocoumon (Marcoumar®)

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Abstract
The effects of ibuprofen on various parameters relating to blood coagulation were studied in nineteen patients adequately anti-coagulated on a fixed dose of phenprocoumon. The patients were studied for a five-week period and they received a fixed dose of phenprocoumon throughout the whole five weeks. Ibuprofen, 200 mg three times daily was added during weeks three and four. The following tests were performed at weekly intervals; Prothrombin time (Quick), Factor II, Factor VII, Factor X, Ivy bleeding time and serum concentration of phenprocoumon. The results showed that in the dosage given, ibuprofen had no significant effect on any of the above tests. It is suggested that the administration of the anti-rheumatic drug, ibuprofen is safe during long-term oral anticoagulation therapy with phenprocoumon.

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