Diffuse Papillomatosis of Rat Urinary Bladder Occurring in Association with Vesical Calculi

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Abstract
Repeated intravesical administrations of 0.9% NaCl solution with or without bladder carcinogen N-butyl-N-(3-carboxypropyl)nitrosamine resulted in a high incidence of calculus formation in the urinary bladder. In those cases, diffuse papillomatosis of the bladder urothelium was observed. Invasion of the tunica muscularis and the tunica adventitia by tumor was demonstrated as early as wk 9 of the experiment. Morphologically, the lesions could not be distinguished from the bladder tumors induced by an orally administered carcinogen. Evidence was presented to conclude that they represent neoplasms of low malignant potential. Apparently, bladder tumors may develop in the absence of known exposure to carcinogen provided the urothelium is chronically stimulated. Tumors solely attributable to N-butyl-N-(3-carboxypropyl)nitrosamine treatment did not occur.