Reversal of Phenylalkylamine Tachyphylaxis by Norepinephrine
- 13 October 1961
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 134 (3485) , 1069-1070
- https://doi.org/10.1126/science.134.3485.1069
Abstract
Since the responses to "neurosympathomimetic amines" are reduced in the reserpinized animal and restored by norepinephrine administration, it was postulated that norepinephrine might also affect the development of their tachyphylaxis. We found that norepinephrine infusion restored, at least partially, certain tachyphylactic responses to amphetamine or ephedrine and fully prevented the development of tachyphylaxis to tyramine.Keywords
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