Iron mobilization from ferritin using α-oxohydroxy heteroaromatic chelators
- 1 January 1986
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 233 (1) , 299-302
- https://doi.org/10.1042/bj2330299
Abstract
Several .alpha.-oxohydroxy heteroaromatic chelators have been shown to mobilize iron from horse spleen ferritin. Although the reactions were slow, taking up to 3 days to reach completion, the amounts of iron mobilized were higher than those reported for other chelators. These results increase the prospects for the clinical use of .alpha.-oxohydroxy chelators in the treatment of iron overload.This publication has 13 references indexed in Scilit:
- NEW ORALLY ACTIVE IRON CHELATORSThe Lancet, 1985
- Ferric ion sequestering agents kinetics of iron release from ferritin to catechoylamidesBiochimica et Biophysica Acta (BBA) - Protein Structure, 1981
- Iron mobilization from ferritin by chelating agentsJournal of Inorganic Biochemistry, 1980
- The binding of ferric iron by ferritinBiochemical Journal, 1979
- Ferritin: structure, biosynthesis, and role in iron metabolism.Physiological Reviews, 1978
- A Mechanism for Ferritin-Iron Oxidation and DepositionBiochemical Society Transactions, 1977
- Mobilisation of iron from ferritin fractions of defined iron content by biological reductantsFEBS Letters, 1975
- The release of iron from horse spleen ferritin by reduced flavinsBiochemical Journal, 1974
- Syntheses of N-Substituted-3-glucosyloxy-2-methyl-4-pyridones and Their AglyconesYAKUGAKU ZASSHI, 1970
- Mobilization of iron from ferritin by chelating agentsBiochemistry, 1968