Probable autosomal dominant infantile pyloric stenosis in a large kindred

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Abstract
The proposita was operated on in a hospital in 1980 for pyloric stenosis, at the age of 13 days, after vomiting had started 5 days previously, and the diagnosis was confirmed on radiological investigation. Her older sister and 2 male cousins of the father had the same operation in Israel in infancy. The other 9 affected individuals in the family were known to have had projectile vomiting for several months in infancy, and 2 of them died in infancy. They were all born in the Jewish community in Georgia, USSR. The male:female sex ratio was 2:2 for the operated cases, and 4:5 for those with projectile vomiting history. There was no skipping of a generation. Evidently, pyloric stenosis can exceptionally be inherited as a simple autosomal dominant trait.

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