CEREBRAL METASTATIC CHORIOCARCINOMA - INTENSIVE THERAPY AND PROGNOSIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 55  (1) , 89-94
Abstract
Choriocarcinoma is sensitive to chemotherapy. Remission rates of 70% are reported for patients with metastatic disease. The treatment of cerebral metastases from choriocarcinoma was reviewed. Fourteen patients were identified as having cerebral metastases from a group of more than 500 patients with gestational trophoblastic disease (GTD) other than primary hydatidiform mole. The remission rate of 50% (7 of 14) was achieved by vigorous multiagent chemotherapy and combined cerebral irradiation therapy. This series of patients is reviewed with regard to diagnosis, details of multiagent chemotherapy with cerebral irradiation, complications and survival. The key factors for successful outcome seem to be early diagnosis and vigorous therapy.

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