Hemodynamic Effects of Changes in Arterial Carbon Dioxide Tension During Intermittent Positive Pressure Ventilation

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Abstract
Hemodynamic effects of changes in arterial carbon dioxide tension during intermittent positive pressure ventilation (IPPV) were studied in lightly anesthetized dogs following recovery from implantation of pulsed ultrasonic flow transducers on aorta and vena cava. Alveolar ventilation was maintained in excess of normal, and arterial PCO2[CO2 pressure] was variedby alteration of inspired CO2 concentration. Data were obtained at PaCO2 20,40, and 60 torr [Torricelli pressure in mm Hg], and at each PaQO2 high (peak airway pressure 30 cm. of water, inspiratory to expiratory ratio of 21) and low (peak airway pressure 10 cm. of water, inspiratory to expiratory ratio of 1:2) levels of ventilation were employed. Two separate hemodynamic effects were observed, the effects of changes in intrathoracic pressure and those produced by alterations in PaCO2. At each PacO2, high level of ventilation decreased stroke volume and cardiac output compared to low level of ventilation. At each level of ventilation, stroke volume and cardiac output were decreased during respiratory alkalosis and increased druing respiratory acidosis.