Amiodarone‐induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA

14 March 1994

journal article
Published by Wiley in FEBS Letters

Vol. 341 (1) , 86-90
https://doi.org/10.1016/0014-5793(94)80245-9

Abstract

Amiodarone decreases plasma and tissue triiodothyronine (T₃) and increases plasma cholesterol levels resembling changes seen during hypothyroidism. To elucidate the mechanism of amiodarone-induced hypercholesterolemia we investigated gene expression of three key proteins in cholesterol metabolism (cholesterol 7α-hydroxylase, LDL receptor, HMG-CoA reductase) in livers of rats. Animals were treated with amiodarone or propylthiouracil (to induce mild hypothyroidism). The LDL receptor mRNA was downregulated (≈50%) in both amiodarone-treated and hypothyroid animals, while the other mRNA remained unchanged after 14-day treatment. The results suggest that amiodarone-induced hypercholesterolemia is associated with decreased LDL receptor mRNA levels.

Keywords

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