Studies on chemotherapy of parasitic helminths (VI) Effects of various neuropharmacological agents on the motility of Dipylidium Caninum.

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Abstract
5-HT [5-hydroxytryptamine] stimulated the motility of D. caninum, while other drugs such as GABA, adrenaline [epinephrine], phenylephrine, isoproterenol, dibenamine and propranolol showed little effect. The stimulatory action of 5-HT was antagonized by tryptophol. Stibnal caused paralysis which was blocked by the pretreatment with 5-HT. Paralytic effects were caused by eserine, dichlorovos, ACh [acetylcholine] carbachol and DMPP [1,1-dimethyl-4-phenyl-piperazinium iodide] but not by pilocarpine and McN-A-343 [4-(m-chlorophenylcarbamoyloxy)-2-butynyl-trimethylammonium chloride]. d-Tubocurarine, hexamethonium and atropine all showed little effect on the motility and on the paralytic action of eserine. Although guanidine showed little effect, strychnine remarkably stimulated the motility. The action of strychnine was stimulated by 5-HT but partially inhibited by tryptophol. Morphine and picrate slightly stimulated the motility, but showed little influence on the paralytic action of eserine. These 2 agents stimulated the paralyzed preparation by tryptophol transiently and sustainedly, respectively. These results on the cholinergic and serotonergic drugs basically showed good agreement with those reported in trematodes such as Schistosoma mansoni and Fasciola hepatica.