Effect of Tranylcypromine on Adrenocortical Secretion in the Dog
- 1 March 1967
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 80 (3) , 510-514
- https://doi.org/10.1210/endo-80-3-510
Abstract
Tranylcypromine in doses of 2 mg/kg or more inhibits the output of 17-hydraxycorticoids from the adrenal following administration of ACTH in the dog. This drug, which has been used clinically as an antidepres-sant, does not interfere with the Porter-Silber method. The increase in 17-hydroxycorticoid secretion produced by angiotensin n is also inhibited. ACTH secretion is not inhibited. The drug reduces the output of cortisol and 11-deaxycortisol while increasing that of corticosterone, 11-deoxycorticosterone and aldosterone. This suggests that it acts by inhibiting adrenocortical 17[alpha]-hydroxylase.This publication has 1 reference indexed in Scilit:
- Suppression of Corticosteroid Production in the Dog by MonaseExperimental Biology and Medicine, 1964