XXX.—HEREDITARY PIGMENTATION OF THE LEG ASSOCIATED WITH ATROPHY

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Abstract
For years we have recognized cases of a peculiar atrophic condition of the skin of the lower third of one leg, never of both legs, associated with deep pigmentation. The disease may be handed down either from the male or the female ancestor, but usually from the latter. It occurs in the lower walks of life, in those who are laborers, and may occur in the male, though far more commonly in the female. It usually begins from the twenty-fifth to the thirty-fifth year, though often it occurs at a younger age. The first symptom is a follicular pigmentation in the lower third of the leg: dots of yellowish, sago-grain pigment irregularly scattered here and there over that portion of the extremity. As the disease progresses, these coalesce into patches of various sizes and shapes. There is usually no pruritus until later. As the accumulation of pigment continues to increase,

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