Red Blood Cell Na+, K+ Pump Activity in Patients on Hemofiltration

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Abstract
The intracellular concentration of Na+ ([Na+i]) and the Na+ efflux mediated by the Na+, K+ pump were evaluated in red blood cells from 9 patients on hemofiltration, 8 on hemodialysis, 9 on continuous ambulatory peritoneal dialysis (CAPD) and 12 normal subjects. [Na+i] was elevated in CAPD patients only. The rate constant for pump-mediated sodium efflux was close to normal in hemofiltration patients, and significantly reduced in hemodialysis (p < 0.03) and CAPD (p < 0.01) patients. Uremic plasma from subjects on hemodialysis and CAPD, but not from hemofiltration, significantly (p < 0.001) inhibited the Na+, K+ pump activity of normal red blood cells. Among our uremic patients those on hemofiltration showed a red blood cell Na+, K+ pump activity close to that of normal subjects, possibly related to the absence in their plasma of a circulating pump inhibitor, that seems invariably present in plasma from hemodialysis and CAPD patients.

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