Dimedone as an Analytical Reagent for the Colorimetric Determination of Paracetamol and Oxyphenbutazone
- 1 January 1986
- journal article
- analytical biochemistry-and-clinical-analysis
- Published by Taylor & Francis in Analytical Letters
- Vol. 19 (3-4) , 479-488
- https://doi.org/10.1080/00032718608064512
Abstract
Dimedone is used here for the colorimetric determination of paracetamol and oxyphenbutazone both in pure form and in their tablets. Paracetamol and oxyphenbutazone are first nitrated and the nitroderivatives produced are extracted into ethyl actetate. Dimedone is added in the presence of triethylamine and a highly coloured complex is formed. The concentration ranges adhering to Beer's law are 0.01 - 0.1 mg/ml for oxyphenbutazone and 0.03 - 0.1 mg/ml for paracetamol.Keywords
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