Rat C-type Virus (BV-1): Effect of Amniotic Fluid, Fetal Serum, and Hormones in Cell Culture,

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Abstract
Bovine amniotic fluid or fetal calf serum markedly reduced the cell alterations which were produced in Wistar/Furth rat embryo cell cultures by a rat C-type virus (BV-1) isolated from chemically-induced mammary tumors. At the same time, higher titers of infectious BV-1 were produced as early as 2 days post-infection in cultures maintained on medium supplemented with bovine amniotic fluid or fetal calf serum as compared to cultures on medium supplemented with newborn calf serum. A similar stimulatory effect on the growth of BV-1 in these cultures was exerted by estrogen (95% natural) which was dose dependent, 1.0-2.5 μg/ml being the most effective dose under the conditions employed. Progesterone had no stimulatory effect on the replication of BV-1 and appeared to be suppressive at higher dose levels.

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