Ruthenium(II) Complex of the Alkaloid 2‐Bromoleptoclinidinone. Preparation and Interaction with Double‐Stranded DNA
- 25 October 1991
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 74 (7) , 1471-1476
- https://doi.org/10.1002/hlca.19910740711
Abstract
The fused pentacyclic alkaloid 2‐bromoleptoclinidinone (1) isolated from an ascidian possesses a bidentate chelating site. Complexation of 1 with [cis‐RuCl2{(D8)bpy}2] · 2H2O forms an octahedral complex which was isolated both as hexafluorophosphate 2 and chloride 3 salts. Intercalation of 3 in calf‐thymus DNA was shown to occur as well as photoactivated cleavage of double‐strand supercoiled DNA pBR322 under visible‐light irradiation.Keywords
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