Tetracyclines and Host-Defense Mechanisms

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Abstract
The effects of different tetracyclines on the bactericidal action of serum and on phagocytosis and intracellular killing of bacteria were investigated. Opsonization, phagocytosis, and intracellular killing were not significantly affected by any of the investigated tetracyclines. The bactericidal action of serum on Escherichia coli was substantially reduced by all tetracyclines investigated. In this respect, doxycycline had a much more pronounced action than the other tetracyclines. The serum bactericidal effect could be completely restored by addition of Mg 2+ .

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