Spatial requirement for coupling of iodotyrosine residues to form thyroid hormones.
- 1 December 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (12) , 5333-5335
- https://doi.org/10.1073/pnas.74.12.5333
Abstract
A linear random copolymer of tyrosine and lysine and 2 synthetic oligopeptides containing 2 tyrosine residues in addition to lysine residues give thyroid hormone (thyroxine and triodothyronine) residues in good yield on enzymatic iodination with thyroid peroxidase. These synthetic peptides may serve as simple models for thyroglobulin, the protein in which biosynthesis of the thyroid hormone takes place. For the formation of significant amounts of hormone, such model compounds must contain at least 2 properly spaced tyrosine residues.This publication has 9 references indexed in Scilit:
- The NH2-terminal region of the beta chain of sickle hemoglobin. I. Synthesis and purification of oligopeptides.Journal of Biological Chemistry, 1976
- Translation of thyroglobulin 33S messenger RNA as a means of determining thyroglobulin quaternary structure.Proceedings of the National Academy of Sciences, 1975
- Elementary chain composition of guinea pig thyroglobulin.Journal of Biological Chemistry, 1975
- Effect of Iodide Concentration on Thyroxine Synthesis Catalysed by Thyroid PeroxidaseEuropean Journal of Biochemistry, 1973
- Peroxydase particulaire thyroïdienneBiochimie, 1972
- Rapid solid-phase synthesis of bradykininBiochemical and Biophysical Research Communications, 1972
- Evidence for a Catalytic Role for Thyroid Peroxidase in the Conversion of Diiodotyrosine to Thyroxine*Endocrinology, 1972
- Iodoamino acid distribution in thyroglobulin iodinated in vivo and in vitroBiochimica et Biophysica Acta (BBA) - Protein Structure, 1972