Pre-emptive administration of corticosteroids prevents the development of ARDS associated withStreptococcus mitis bacteremia following chemotherapy with high-dose cytarabine

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Abstract
Adult respiratory distress syndrome (ARDS) complicatingStreptococcus mitis bacteremia is a major cause of mortality in patients undergoing therapy for leukemia. In order to try to prevent the development of ARDS in 11 patients withS. mitis bacteremia following chemotherapy including cytarabine, high doses of corticosteroids were administered pre-emptively. None of these patients developed ARDS. In a historical control group of 21 comparable patients who had not been given corticosteroids, the incidence of ARDS was high (38%), with a death rate of 14%. Preemptive administration of high-dose corticosteroids appeared to be highly effective in suppressing the mechanisms that induce ARDS in patients withS. mitis bacteremia after cytarabine treatment. The results suggest that ARDS complicatingS. mitis bacteremia is not merely a microbiological problem but may, at least in part, represent an immunologically mediated phenomenon.