An Electron Microscope Study of Darier’s Disease

Publisher Website
Google Scholar
Abstract
The author gives a description of the appearance in the electron microscope of the epidermis in Darier''s disease. From these findings conclusions can be drawn as to the pathomechanism of Darier''s disease which seems to be a dysfunction of the mechanism by which the intercellular linkages of the epidermis are formed. These linkages, manifest as prickles or desmosomes, normally consist of tonofibrils. The formation of corps ronds and grains as well as of clefts is ascribed to the failure, wholly or partially, of individual cells to form prickles. Consequently, these cells do not remain attached to each other, become rounded, and part easily from neighboring cells, i.e. form corps ronds. Similarly the origin of clefts can be explained. The cytoplasms of affected cells appear to be very granular, the nuclei lobulated, phenomena which cannot be explained presently. In the basal cells "unknown bodies" were present which finding presumably points at premature cornification of lesion cells.

This publication has 1 reference indexed in Scilit: