The 5-endo-trig Cyclization of gem-Difluoroolefins with sp3 Carbon Nucleophiles: Synthesis of 1-Fluorocyclopentenes
- 1 March 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 31 (3) , 282-283
- https://doi.org/10.1246/cl.2002.282
Abstract
A disfavored 5-endo-trig cyclization is accomplished in gem-difluoroolefins with sp3 carbon nucleophiles, generated via the lithium–iodine exchange reaction of 1,1-difluoro-5-iodo-1-pentenes with tert-butyllithium, to afford 1-fluorocyclopentenes.Keywords
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