Radiation Effect on Intraocular Tissues in Radon Seed Treatment of Retinoblastoma

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Abstract
For some time now, ophthalmologists have been attempting to save the less involved eye in bilateral retinoblastoma with radiation therapy. The results with x-ray therapy alone have generally been disappointing. Although retinoblastoma is radiosensitive, the dose lethal to the tumor approaches the tolerance of normal structures in the posterior part of the eye and exceeds the tolerance of the structures of the anterior part of the eye.1The relatively narrow margin between the cancericidal dose and the dose tolerated by normal ocular tissues has given rise to many complications with x-ray therapy.2The complication of gravest concern is late vitreous hemorrhage from damaged retinal blood vessels.3In order to reduce the incidence of complications, the dosage of x-ray has been decreased by employing along with it a radiomimetic drug, such as the nitrogen mustards4or, especially, triethylene melamine (TEM).3The results of this combined therapy

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